Summary
The human body has a protective shield between the bloodstream and the central nervous system (CNS). This shield includes the blood-spinal cord barrier (BSCB). The BSCB strictly controls which molecules enter the spinal cord. A damaged or compromised BSCB can contribute to neurological disorders, including spinal cord injuries and Amyotrophic Lateral Sclerosis (ALS). Studying these diseases or testing new treatments is challenging, because researchers do not have laboratory models that accurately mimic the BSCB. This CAREER project will bioengineer a "BSCB-on-a-chip." The project will use adva
