Summary
PROJECT SUMMMARY/ABSTRACT Transcriptional enhancers are non-coding DNA elements that control the expression of their target genes with spatiotemporal specificity. Transcription factors confer the specificity of enhancer function by recruiting core transcriptional machinery to the enhancer’s target promoter during gene activation. Altered enhancer function may yield a variety of pathologies, including congenital anomalies. However, even under adverse environmental and genetic conditions, most births occur without congenital anomalies, attesting to the resilience of developmental programs. This
