Summary
With the support of the Chemistry of Life Processes Program in the Chemistry Division, Jie Li from the University of South Carolina is studying how nature uses enzymes to incorporate and modify sulfur centers in microbial secondary metabolites. These natural products provide a competitive advantage to the producing microbes while also conferring significant fundamental value in medicinal, manufacturing, agricultural applications. In contrast to extensively studied sulfur incorporation in primary metabolism (e.g., nucleotides and amino acids), there is a gap in the general understanding of the
