Summary
Abstract Complex regional pain syndrome (CRPS) is a chronic pain disorder of unknown etiology that can affect one or more extremities. Difficulty in treating CRPS stems from incomplete understanding of the underlying mechanisms. Despite different clinical presentations, clear evidence for altered processing of sensory stimuli leading to allodynia, hyperalgesia, and hyperaesthesia has been demonstrated in CRPS. Aberrant immune function is reported to contribute to CRPS pathology. Autoinflammatory and autoimmune mechanisms in the skin of the affected limb, and systemically in circulation, report
