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Fluidic Protein Vesicles for High-Density Signal Presentation in Immunomodulatory Biomaterials

US NSF grant open #nsf-2532798

Summary

PART 1: NON-TECHNICAL SUMMARY Living cells constantly communicate and respond to their surroundings using complex molecular interactions on their surfaces. Many life-saving immunotherapies, such as engineered T cells used to fight cancer, rely on these surface interactions to activate the immune system. However, building artificial systems that can reliably mimic these natural signals has been very difficult. Current synthetic materials cannot easily control how proteins cluster, move, and organize on a surface, even though these features are essential for proper immune activation. This pro

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