Summary
- Mechanisms of non-Mendelian segregation through female meiosis To understand how meiotic drive elements achieve non-Mendelian segregation, we currently focus on selfish centromeres in mice. Expanded centromeric satellite repeats can violate Mendel's law of segregation by preferentially segregating to the egg cell. In mice, these selfish centromeres enrich microtubule destabilizers (Aurora B kinase and kinesin-13 MCAK) at pericentromeres to detach from the spindle and flip toward the egg side of the meiotic spindle, thereby achieving preferential segregation. However, despite the consistent
