Summary
Intestinal epithelial cells reside at the direct interface between the microbiota and mammalian host, and are thus uniquely poised to sense microbial signals that calibrate intestinal immunity and function. Tuft cells are a specialized epithelial cell that have recently been shown to respond to microbial stimuli and initiate and amplify type 2 immune responses in the intestine. However, despite a clear relationship between the microbiota and intestinal health, the mechanisms underlying how the microbiota instruct tuft cell homeostasis and function remain poorly understood. Epigenetics represen
