Summary
PROJECT SUMMARY/ABSTRACT Despite cancer being typically depicted as a genetic disease, aberrations in epigenetics and gene expression play a determinant role in transformation and response to therapies. Derailed from their developmental paths, malignant cells may arrest their differentiation fate and activate alternative programs. Aberrant chromatin plasticity gives a survival advantage by expanding the repertoire of epi-clones and allowing them to react to the immune system, environmental stress, or exogenous treatments. Investigating which genetic and epigenetic aberrations alter chromatin h
