Summary
PROJECT SUMMARY/ABSTRACT In this proposed work, we seek to understand the cellular identity of macrophages, the main immune cells in the cochlea, in noise-induced hearing loss (NIHL). Our previous studies have shown that macrophages in the brain have different developmental origins and their origin is associated with differences in their cellular identity and functions depending on each disease condition. At present, the cellular identities and functional properties of macrophages after noise damage are not well understood. Combining macrophage fate-mapping analysis with single-cell RNA sequen
