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Measuring and Modeling the Effects of Reticular Lamina Flexibility on Outer Hair Cell Bundle Phase and Cochlear Amplification

US National Institute on Deafness and Other Communication Disorders grant open #nih-5F31DC021079-03

Summary

ABSTRACT The mammalian auditory system has evolved into a biological marvel with high sensitivity that can largely be traced to nonlinear amplification by the organ of Corti (OoC)—the sensory epithelium within the cochlea of the inner ear. Despite decades of research, the inaccessibility of the inner ear’s bony capsule and the technological challenges of measuring and modeling nanometer-scale vibrations in a multi-physics system have made it difficult to uncover OoC structure-function relationships. However, increased computational capabilities and novel imaging technologies such as optical co

Measuring and Modeling the Effects of Reti…
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