Summary
PROJECT SUMMARY Tissue specification, growth, maintenance, and regeneration rely on spatiotemporal cues provided by the evolutionarily conserved Wnt morphogen pathway. Many developmental disorders and cancers, including nearly all colorectal cancers, arise when the normal regulation of Wnt signal transduction is lost; yet key mechanisms that mediate essential steps in this pathway remain poorly understood. An improved mechanistic understanding of Wnt pathway activation is therefore crucial, as no drugs that target Wnt-driven disease have yet been approved by the FDA. The long-term goals of the
