Summary
A Cereblon Signaling Network in Wnt-driven Cancers Abstract The long-term objective of this study is to investigate how Cereblon (CRBN) regulates the Wnt signal transduction pathway and to demonstrate how this can be exploited to target Wnt-driven colorectal cancers (CRCs). Wnt signaling is essential for intestinal stem cell maintenance and aberrant activation of this pathway drives the initiation and progression of nearly all CRCs. To date, no drugs that inhibit the Wnt pathway have been FDA- approved, partly due to the lack of druggable targets that can bypass common Wnt pathway mutations in
