Summary
Project Summary: Rett Syndrome (RTT) is a progressive neurological disorder characterized by severe cognitive and motor impairments caused primarily by mutations in MECP2. The molecular mechanisms by which disruption of MECP2 gives rise to RTT remain unclear. MECP2 is known to bind to methylated DNA in the brain, regulating the expression of neuronal genes. However, previous studies have shown complex patterns of gene dysregulation in RTT that challenge this model, such that only a subset of genes appear to be regulated by MECP2 binding to DNA methylation. We recently discovered that MECP2 pre
