Summary
Malignant melanoma is one of the deadliest forms of cancer among Veterans, and the existing therapeutic options have not been fully effective in melanoma management, primarily owing to acquired drug resistance. Therefore, novel target-based approaches are needed for the management of this neoplasm. The mammalian sirtuins belong to a family of seven members (SIRT1 – SIRT7) with NAD+-dependent protein deacetylase and/or ADP-ribosyltransferase activities, which play critical roles in important cellular processes, and are involved in a variety of diseases, including cancer. We have an ongoing prog
