Summary
Metastasis is the spread of tumor cells through blood or the lymph system to form new tumors in otherwise healthy organs. Circulating tumor cells (CTCs) in the bloodstream often form clusters of CTCs. Some evidence suggests that when CTCs form clusters, they become more resistant to the body’s immune responses. However, other evidence suggests that cluster formation does not significantly affect metastasis. This CAREER project will use computer modeling and artificial intelligence (AI) to examine CTC clusters in the circulatory system. Simulations will describe how CTC clusters move through t
