Summary
Project Abstract The protozoan parasite Cryptosporidium is a leading cause of diarrheal disease (cryptosporidiosis) and death in young children and immunocompromised individuals. Currently, there are no vaccines or effective drugs to prevent or treat cryptosporidiosis. Our understanding of the interactions of Cryptosporidium with its host cell is very limited. Cryptosporidium has a unique mode of invasion that differs from other related apicomplexan parasites. The parasite creates an ‘intracellular but extracytoplasmic’ niche where it sits on top of the intestinal epithelial cell, engulfed by
