Summary
The Role of Hypothalamic Dysfunction in Accelerating Human Aging Sandra Aleksic, MD, M.S. Mentor: Sofiya Milman, MD, M.S. Co-mentors: Michael Lipton, MD, PhD; Joe Verghese, MBBS, MS Abstract: Mechanisms underpinning biological aging in humans remain incompletely understood. The hypothalamus integrates key metabolic and neuroendocrine longevity pathways; therefore, hypothalamic dysfunction could accelerate aging in humans. Recent studies in rodents identified aging-related hypothalamic microinflam- mation, referred to as gliosis, which was characterized by accumulation and activation of microg
