Summary
Mismatch repair (MMR) factors, which act to remove DNA replication misincorporation errors, also function in genetic recombination and in adaptation to stress. The latter two roles are the current focus of my research efforts. Research Area 1 is centered on crossing over, a process critical in most eukaryotes for the accurate segregation of homologous chromosomes in meiosis to form gametes. Most crossovers in baker’s yeast meiosis result from the biased resolution of double Holliday Junction (dHJ) intermediates in steps involving Exo1 and the Mlh1-Mlh3 MMR endonuclease, a process conserved in
