Summary
The recognition and binding of nucleic acids by proteins is a central phenomenon in biology, governing processes that range from the flow of genetic information to viral infection and propagation. Despite the importance, our current understanding fails to capture the conformational complexity and dynamic nature of the recognition and binding process. Molecules like RNA exist as an ensemble of accessible conformations, including rare conformations that are not observable using traditional measurements but can be biologically active. Furthermore, a huge span of timescales can be relevant in the
