Summary
Understanding how genes are turned "on" or "off" (regulatory control) is central to biology, medicine, and biotechnology. Although the human genome has been extensively mapped, scientists still do not know whether the linear arrangement of DNA elements encodes an underlying design logic governing how groups of genes are activated together. This project tests the idea that the functional behavior and three-dimensional organization of the genome are encoded in its linear structure. By systematically re-engineering the spacing and organization of regulatory elements to control coordinated gene ac
