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Functional analysis of a novel cell envelope integrity protein in Brucella ovis

US National Institute of Allergy and Infectious Diseases grant open #nih-5F32AI174818-03

Summary

Abstract The long-term goal of this research is to determine how bacteria maintain cell envelope integrity in the face of harsh and fluctuating environmental conditions. The cell envelope of Gram-negative bacteria is composed of the cytoplasmic membrane, peptidoglycan cell wall, and the lipopolysaccharide (LPS)-containing outer membrane. In the intracellular pathogens, Brucella spp., the composition of the LPS is critical for virulence and persistence in the host. Our group recently identified a periplasmic protein of unknown function, named EipA, that is conserved across the class Alphaproteo

Functional analysis of a novel cell envelo…
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