Summary
PROJECT SUMMARY More than 30 million Americans have pre- or existing diabetes. An innovative approach to treat diabetes is to generate functional insulin-producing -cells for transplantation in vitro. This approach is currently in clinical trials, but a recognized problem is suboptimal progenitor generation. -cells originate from a multipotent progenitor population in the early pancreatic epithelium. Elucidating mechanisms that regulate progenitor specification and maturation in vivo using mouse models will instruct in vitro differentiation efforts. The Hippo pathway is emerging as a key mec
