Summary
PROJECT SUMMARY/ABSTRACT Given their physiochemical properties, medications and dietary supplements often require active transport using solute carriers (SLC) and ATP-binding cassette (ABC) transporters to cross trophoblast barriers. These same transporters are also involved in the delivery of nutrients to the fetus and one unintentional consequence of drug therapy during pregnancy can be disruption of these shared systems. Therefore, understanding the interplay between SLC and ABC transporters in the placental disposition of drugs and nutrients is one key step to optimizing therapeutic interv
