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Wiring and rewiring of the chromatin landscape during retinogenesis

US National Eye Institute grant open #nih-5R01EY035619-02

Summary

SUMMARY: The proper execution of transcriptional programs in retinal progenitor cells is extremely critical for retinal formation as dysregulation of this process leads to severely compromised retinogenesis and the development of ocular disorders, including anophthalmia or microphthalmia. The wiring and rewiring of chromatin landscape constitutes an essential mechanism to precise spatial and temporal regulation of gene expression during retinal differentiation, yet our understanding to this process remains inadequate. Our goal is to utilize state-of-the-art genomic technologies to provide a de

Wiring and rewiring of the chromatin lands…
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