Summary
SUMMARY The long-term goal of this study is to increase our understanding of the immune mechanisms involved in the pathogenesis of allergic diseases and asthma. Allergic asthma is a chronic inflammatory disorder that is characterized by airway hyperreactivity (AHR) and driven by Th2 cytokine production. Group 2 innate lymphoid cells (ILC2s) secrete high amounts of Th2 cytokines and contribute to the development of AHR. This project is motivated by our published results (Maazi et al., Immunity), demonstrating that ICOS is extensively used by activated ILC2s to maintain their homeostasis and eff
