Summary
During endocytosis, the cell's plasma membrane is deformed and internalized to bring in extracellular cargo and transmembrane receptors. Nonclathrin/noncaveolar (CLIC/GEEC) endocytosis internalizes glycosylated receptors and extracellular fluid, and is connected to cell polarity development, blebbing, and the epithelial-to-mesenchymal transition during cancer metastasis. A molecular and mechanical understanding of CLIC is necessary to understand how CLIC coordinates membrane curvature and actin polymerization to internalize the plasma membrane against membrane tension. The primary limitation
