Summary
Project Summary/Abstract Amyotrophic Lateral Sclerosis (ALS) is the third most common neurodegenerative disease, with no cure and limited treatment options. While motor neurons are primarily affected, non-neuronal cells, particularly myeloid cells (microglia and peripheral macrophages), significantly influence disease progression. Our preliminary studies identified α5 integrin as a novel molecular switch that emerges in myeloid cells during ALS progression and correlates with inflammatory states in both familial and sporadic ALS patients. Importantly, blocking α5 integrin significantly extends
