Summary
PROJECT SUMMARY Sleep spindle deficits are a promising biomarker and therapeutic target for schizophrenia spectrum disor- der (SSD), as they reflect underlying dysfunction in thalamocortical circuits. However, current non-invasive neuromodulation techniques lack the depth and precision to directly target deep brain structures like the thala- mus, where sleep spindles are generated. Temporal interference transcranial electric stimulation (TI-TES) of- fers a novel approach to selectively stimulate deep brain regions, such as the thalamus, while minimizing elec- tric fields elsewhere. Additional
