Summary
Project Summary Azoles are ubiquitous amongst bioactive molecules, present in approximately one third of commercial pharmaceuticals. However, selective preparation of N-alkylated azoles is an outstanding synthetic challenge. As a result, stereochemistry and N-regioselectivity are often achieved through the separation of isomeric mixtures or introduced during de novo ring synthesis. This approach creates a significant synthetic barrier when evaluating analogs of bioactive molecules during drug discovery campaigns. Therefore, a selective method to install alkyl fragments on existing azoles is po
