Summary
PROJECT SUMMARY/ABSTRACT When the airways of children dependent on ventilators become infected with multi-drug resistant (MDR) organisms, such as Klebsiella pneumoniae (KP), their risk of acute deterioration and even death increases. Difficult to eradicate, MDR KP have been identified as a major threat to human respiratory health. Therefore, studying the mechanisms of how the lung is affected by MDR bacteria is very important for this high-risk patient population. One hypothesis for their success is that the change in the inflammatory milieu is a direct result of the altered metabolic environm
