Summary
PROJECT SUMMARY Tuberculosis (TB), caused by the intracellular pathogen Mycobacterium tuberculosis (Mtb), infects one-fourth of the world’s population. Majority of the infected individuals are latently infected (LTBI), of which 5-10% stand a risk of progressing to active TB disease (ATB) during their lifetime. There is limited knowledge about the precise mechanisms and pathways that mediate protective versus pathologic immunity during TB. Using RNA- sequencing analysis, we recently identified novel immune pathways upregulated during TB latency across species, namely Bone Morphogenetic Protein
