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Pre- and Postnatal Exposure to Air Pollutants and the Gut Microbiome: Implications for Brain Development in Early and Mid-Childhood

US National Institute of Environmental Health Sciences grant open #nih-5R01ES035056-04

Summary

ABSTRACT Early life exposure to air pollution (AP), which disproportionately affects underserved communities, is thought to disrupt cognitive, emotional, and behavioral development. Human studies show that exposure during the prenatal and early postnatal periods are associated with developmental delays, autism, more severe attention- deficit hyperactivity disorder, depression, and anxiety. Increasing evidence also suggests that exposure to AP is associated with variation in the human gut microbiome, which other evidence suggests can alter brain physiology and cognitive development. Despite the

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