Summary
Project Summary/Abstract Multiple Sclerosis (MS) is a chronic inflammatory, neurodegenerative disease involving the destruction of myelin sheaths on neurons resulting in axonal damage leading to permanent functional deficits including paralysis and loss of vision. In MS, the blood-brain barrier is disrupted allowing fibrinogen to enter the brain and fibrinogen is a driver of neuropathology. It prevents remyelination and repair of damaged neurons by blocking multipotent oligodendrocyte progenitor cells (OPCs) from differentiating into myelin producing oligodendrocytes (OL) and directs OPC cell
