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The interplay of maternal antibody and newborn vaccine responses

US National Institute of Allergy and Infectious Diseases grant open #nih-5R01AI189601-02

Summary

Young infants are at high risk for severe disease following influenza virus infection. The current strategy for protecting infants is to increase antibody in the mother that can be transferred across the placenta to the fetus such that infants are born with influenza virus-specific antibodies on board. However, while maternal antibodies can decrease the likelihood that infants develop influenza disease, in many cases this protection is incomplete and infants remain at high risk. Further, maternal antibody will wane in all infants, leaving them more susceptible to infection. The combination of

The interplay of maternal antibody and new…
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