Summary
Proteins are essential to life and play central roles in medicine, biotechnology, and sustainable manufacturing. They enable critical chemical reactions that support human health, environmental processes, and industrial production. However, improving protein function remains a major challenge because current approaches often rely on trial-and-error methods or static structural information, which do not fully capture how proteins carry out complex chemical transformations. In particular, there is limited understanding of how energy flows from the solvent into proteins to enable and regulate the
