Summary
The regulation of oxygen in brain tissue is a fundamental question in neuroscience and medicine, as it is crucial for maintaining optimal brain function. GABAergic interneurons, which provide inhibitory signals in the cerebral cortex, have been found to not only connect with other neurons but also with arterioles, enabling them to control network activity and vasomotion to regulate blood delivery within the brain. However, the specific mechanisms by which interneurons contribute to local oxygen homeostasis remain unclear. Building upon our published and preliminary data, we propose that intern