Summary
This CAREER project will develop new ways to reshape living tissues for tissue engineering and regenerative medicine. Nature shapes organs and tissues by selectively removing cells in a process called apoptosis. This project will use spatially patterned light to induce apoptosis selectively to shape tissues. The high-resolution process will selectively remove cells while leaving neighboring cells intact. The team will test this approach in laboratory models of heart and liver tissue made from human induced pluripotent stem cells (iPSC). The goals will be to open channels for blood flow, mo
