Summary
PROJECT SUMMARY/ABSTRACT Duchenne muscular dystrophy (DMD) is a severe and progressive neuromuscular disease that affects 1:5000 live male births, making it the most common form of muscular dystrophy. DMD is caused by the disruption of the DYSTROPHIN gene that results in the production of a non-functional or absent dystrophin protein. Lack of dystrophin in muscle results in myofiber death and fibrosis that can result in fatal cardiac arrhythmia and/or respiratory failure in end-stage DMD patients. Interestingly, many DMD patients report sleep disruption, nighttime sleep/wake disruptions, noctu
