Summary
The supported project studies how microorganisms sense and respond to carbon monoxide (CO) in the environment. CO garners a poor reputation as an imperceptible and lethal gas; however, CO is also a biological signal generated as a metabolic by-product in nearly all organisms on Earth. Such “endogenously produced” CO regulates cellular processes, including cell growth, cell death, and inflammation. CO is also a metabolic intermediate and nutrient for certain microorganisms, serving as a viable source of energy for microbes in nutrient-poor environments. Being a signal and nutrient, CO holds gre
