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RNA:RNA interactions regulating virulence gene expression in Listeria

US NSF grant open #nsf-2544759

Summary

Bacteria must sense and respond to their changing environments. In particular, the coordinated expression of virulence genes, proteins that give the bacterium the ability to cause disease, is essential for bacterial fitness. Listeria monocytogenes is a foodborne pathogen that causes severe disease and results in significant public health concerns, economic burden, and societal costs. RNAs play a central regulatory role in gene expression and can sense and respond to the changing host environment, including temperature and metabolite concentrations. Interestingly, two L. monocytogenes RNAs work

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