Summary
Project summary/abstract Cardiovascular disease is the leading cause of death worldwide, and overactivity of the sympathetic branch of the autonomic nervous system (sympatho-excitation) plays a key role in the pathogenesis or progression of numerous cardiovascular diseases. Overactivity of cardiac sympathetic neurons leads to increased release of neuropeptide Y (NPY), the major neuropeptide in the heart. Excess NPY release has been correlated with worse outcomes in heart failure, where it is speculated to be arrhythmogenic and contribute to sudden cardiac death. Our long-term goal is to unders
