Summary
In this project, we aim to translate a fluorine-19 (19F) MRI technology to visualize the tumor associated macrophage (TAM) burden in patients with recurrent head and neck squamous cell carcinoma (HNSCC). HNSCC is the sixth most common cancer worldwide. TAMs often comprise a significant volume fraction of tumor mass, and a high TAM burden in the tumor microenvironment is associated with poor therapeutic prognosis. In HNSCC patients developing locoregionally recurrent or metastatic disease, anti-PD-1 antibody checkpoint inhibitor therapy is currently the standard of care, however, the response r
