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Recombinant Bolaamphiphilic Protein Engineering for Asymmetric Vesicle Formation toward Synthetic Cell Signal Transduction

US NSF grant open #nsf-2540253

Summary

This project addresses a fundamental challenge in synthetic biology: how to design cell-like systems that can sense their environment and process information in a controlled and programmable way. Living cells rely on asymmetric membranes and precisely organized proteins to convert external signals into internal responses, enabling essential functions such as communication, recognition, and adaptation. However, recreating these capabilities in synthetic systems remains a major scientific barrier. This research will develop a new class of fully protein-based vesicles that mimic these key cellula

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