Summary
Project Summary (Abstract) Urinary tract infections (UTI) are one of the most common bacterial infections and are caused predominantly by uropathogenic Escherichia coli (UPEC). While broad-spectrum antimicrobials have been the drug of choice to treat UTIs, the emergence of antimicrobial drug resistance and related recurrent UTI suggests that this is not an effective approach to treat all UTIs. Hence, further understanding of the intrinsic host defense mechanisms during bladder and kidney infection should provide new targets for selective, antimicrobial-sparing therapeutic approaches. There is
