Summary
PROJECT ABSTRACT This proposed career development award will provide Dr. Danielle Alfano, MD with targeted mentored training to ensure she develops into an independent researcher utilizing both experimental approaches, mouse models, and “omics”, to probe how specific pathogens harness ADAM10 leading to the dysregulated endothelial and host response in sepsis. Sepsis is a complex syndrome defined as a ‘dysregulated host response to infection leading to life-threatening organ dysfunction’. While many studies in the field have focused on an aberrant host immune response as the instigator of sever
