Summary
PROJECT SUMMARY Chronic itch is a considerable medical challenge associated with various skin and systemic diseases, , exerting a profound impact on patients' overall quality of life. While the epidermis is conventionally considered the source of skin itch, critical knowledge gaps persist regarding the role of Langerhans cells (LCs), resident cells in the epidermis, in mediating itch. LCs play a vital immunologic role in protecting against environmental antigens and, due to their dendrite-like appearance and proximity to nerve endings, have been associated with the nervous system. This projec
