Summary
PROJECT 1 – STRUCTURAL BIOLOGY OF DNA DEAMINASES IN CANCER ABSTRACT The human APOBEC3 (A3) family of deaminases catalyze the conversion of cytosine to uracil in single- stranded DNA to elicit mutations and genome instability, which in turn promote tumor evolution and the development of therapy resistance and metastatic disease. However, despite the large overall impact of A3- mediated mutagenesis in human cancer and the likely benefits of inhibiting A3-mediated mutagenesis, targeting the A3 family of deaminases for catalytic inhibition and/or selective degradation has remained unfulfilled, ch
