Summary
Glioblastoma (GBM) is the most common malignant primary brain tumor, with a median survival of 12-15 months. Despite surgical resection and adjuvant therapy, the tumor inevitably recurs. GBM transcriptional states, which are diverse and driven by distinct gene expression programs, are critical determinants of the response to therapy and prognosis. To find new treatments to block GBM progression, we need a better understanding of gene expression regulation which underlies the diverse transcriptional states in GBM. In the proposed work, we will investigate how physical force regulates GBM transc
