Summary
PROJECT 3: PROJECT SUMMARY Recent studies connected 3D nuclear and chromosomal architecture to the regulation of gene expression in multiple tissues and cell types. PIs in this Program Project were some of the first to link 3D topology to cellular transformation in human leukemia. We identified mutations that can impact DNA looping (targeting CTCF and the Cohesin complex) and mapped nuclear topology in T cell leukemia (T-ALL). Also, in collaboration with the Computational Core, we developed and refined computational tools that enable us to study such 3D interactions in cancer genomes, starting
