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Deconstructing interactions between diet, microbiome, and immunity to gain mechanistic insight into health and disease

US National Institute of Allergy and Infectious Diseases grant open #nih-5R00AI159227-04

Summary

Project Summary/Abstract Intestinal immune responses are linked to the trillions of microorganisms that colonize the gastrointestinal tract. Thus, inter-individual variations in the gut microbiome could contribute to altered immune responses that impact immune driven diseases such as autoimmunity. Activation of T helper 17 (Th17) cells by members of the gut microbiota can contribute to autoimmunity. Further, evidence is emerging that the diet influences both the immune system and the microbiome. While the pairwise interactions between dietary factors, the microbiota, and immunity have been bro

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